Required for normal hepatic glucose formation. What stimulates an ACTH rise? Stress What is the function of cortisol? Mobilises AA from skeletal muscle, stimulate AA uptake from liver and induction of hepatic enzymes for GNG. If there was no cortisol ACTH and CRH would remain high. What inhibits cortisol? It has a negative feedback system where it inhibits its own production by acting at the anterior pituitary and hypothalmus. ACTH travels around the body i the jugular vein. What stimulates glucocorticoids (cortisol)? ACTH (adrenocorticotrophic hormone), which is dependent on CRH (corticotrophin releasing hormone). androgens What is the function of the sex steroids? They are considered unimportant because the amount produced by the adrenal gland is small. What does the cortex secrete? Mineralocorticoids eg. adrenaline What is the medulla? A sympathetic nervous system ganglion which secretes adrenaline and sometimes noradrenaline into the bloodstream rather than innervating post-ganglionic fibres What is the neurotransmitter that activates the medulla? Noradrenaline What is the function of catecholamines? Back up for sympathetic nervous system, fight/flight, importantly it increases availability of glucose and stimulates K uptake by cells to maintain ECF. Zona reticularis Inner most region, a tangle of cells What does the medulla secrete? Catecholamines eg.
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